How NCRIS infrastructure helped UQ’s vaccine platform: a billion-dollar success

19 February 2026
Image of molecular clamp COVID-19 vaccine candidate (right) reconstructed from cryo-electron microscope data collected using the instrument pictured above. By Naphak Modhiran, Daniel Watterson, and Lou Brillault. Read more about it here.

 

Lou Brillault changing a sample in the cryo electron microscope at CMM, which was used for the molecular clamp research.

A landmark deal has placed Australian vaccine innovation on the world stage and CMM has provided integral expertise and infrastructure to help deliver manufacturing, process development and analytical testing to support the translation of research discovery towards clinical trials.

Invented by Professor Keith Chappell, Professor Daniel Watterson and Emeritus Professor Paul Young, the Molecular Clamp platform allows researchers to stabilise viral proteins in a shape that better triggers the immune system. It first came to global attention during the COVID-19 pandemic through UQ’s partnership with the Coalition for Epidemic Preparedness Innovations (CEPI). 

Read full article here.

A few statements from the lead Scientists:

Professor Dan Watterson

Thanks to Roger and the CMM team for the support over years, visualizing what we were making was not only important to the science but was also integral to getting funding/investment for the platform.

Professor Keith Chappell

Fully agree with Dan. The growing collection of structures confirming the quality of the vaccines we've produced is extremely important to the various pitch slides we've presented at all stages. Big thanks to the CMM team.

Emeritus Professor Paul Young

The structural component of the work was integral. Thank you for your support.

(L-R) Professor Keith Chappell, Professor Daniel Watterson and Emeritus Professor Paul Young, inventors of the Molecular Clamp technology.

 

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